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Published Research

Our researchers and staff have published a large body of high-quality research on cancer and chronic kidney disease, as well as other health topics such as screening, survivorship, palliative care, sustainability, equity and health services.

For a list of our journal articles, visit PubMed.

Featured CCO Research Articles

Araghi M, Fidler-Benaoudia M, Arnold M, Rutherford M, Bardot A, Ferlay J, Bucher O, De P, Engholm G, Gavin A, Kozie S, Little A, Møller B, St Jacques N, Tervonen H, Walsh P, Woods R, O'Connell DL, Baldwin D, Elwood M, Siesling S, Bray F, Soerjomataram I; ICBP SURVMARK-2 Local Leads; ICBP SURVMARK-2 Academic Reference Group; ICBP Clinical Committee–Lung. International differences in lung cancer survival by sex, histological type and stage at diagnosis: an ICBP SURVMARK-2 Study. Thorax. 2021 Jul 19:thoraxjnl-2020-216555. doi: 10.1136/thoraxjnl-2020-216555. Epub ahead of print. PMID: 34282033.

Beca JM, Chan KKW, Naimark DMJ, Pechlivanoglou P. Impact of limited sample size and follow-up on single event survival extrapolation for health technology assessment: a simulation study. BMC Med Res Methodol. 2021 Dec 18;21(1):282. doi: 10.1186/s12874-021-01468-7. PMID: 34922454.

Blake P, Hladunewich M, Oliver M. COVID-19 Vaccination Imperatives in People on Maintenance Dialysis. Clin J Am Soc Nephrol. 2021 Nov;16(11):1746-1748. doi: 10.2215/CJN.07260521. Epub 2021 Jul 19. PMID: 34281983.

Blake PG, McCormick BB, Taji L, Jung JK, Ip J, Gingras J, Boll P, McFarlane P, Pierratos A, Aziz A, Yeung A, Patel M, Cooper R. Growing home dialysis: The Ontario Renal Network Home Dialysis Initiative 2012-2019. Perit Dial Int. 2021 Sep;41(5):441-452. doi: 10.1177/08968608211012805. Epub 2021 May 10. PMID: 33969759.

Brooks JD, Nabi HH, Andrulis IL, Antoniou AC, Chiquette J, Després P, Devilee P, Dorval M, Droit A, Easton DF, Eisen A, Eloy L, Fienberg S, Goldgar D, Hahnen E, Joly Y, Knoppers BM, Lofters A, Masson JY, Mittmann N, Paquette JS, Pashayan N, Schmutzler R, Stockley T, Tavtigian SV, Walker MJ, Wolfson M, Chiarelli AM, Simard J. Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I). J Pers Med. 2021 Jun 4;11(6):511. doi: 10.3390/jpm11060511. PMID: 34199804.

Chang VC, Cotterchio M, De P, Tinmouth J. Risk factors for early-onset colorectal cancer: a population-based case-control study in Ontario, Canada. Cancer Causes Control. 2021 Oct;32(10):1063-1083. doi: 10.1007/s10552-021-01456-8. Epub 2021 Jun 13. PMID: 34120288.

Cheung MC, Franco BB, Meti N, Thawer A, Tahmasebi H, Shankar A, Loblaw A, Wright FC, Fox C, Peek N, Sim V, Singh S. Delivery of Virtual Care in Oncology: Province-Wide Interprofessional Consensus Statements Using a Modified Delphi Process. Curr Oncol. 2021 Dec 13;28(6):5332-5345. doi: 10.3390/curroncol28060445. PMID: 34940084.

Chiarelli AM, Walker MJ, Espino-Hernandez G, Gray N, Salleh A, Adhihetty C, Gao J, Fienberg S, Rey MA, Rabeneck L. Adherence to guidance for prioritizing higher risk groups for breast cancer screening during the COVID-19 pandemic in the Ontario Breast Screening Program: a descriptive study. CMAJ Open. 2021 Dec 21;9(4):E1205-E1212. doi: 10.9778/cmajo.20200285. PMID: 34933878.

Clark M, Jembere N, Kupets R. The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts. Prev Med. 2021 Sep;150:106641. doi: 10.1016/j.ypmed.2021.106641. Epub 2021 May 25. PMID: 34048822.

Dai WF, Arciero V, Craig E, Fraser B, Arias J, Boehm D, Bosnic N, Caetano P, Chambers C, Jones B, Lungu E, Mitera G, Potashnik T, Reiman A, Ritcher T, Beca JM, Denburg A, Mercer RE, Parmar A, Tadrous M, Takhar P, Chan KKW, On Behalf Of The CanREValue Collaboration Reassessment And Uptake Working Group. Considerations for Developing a Reassessment Process: Report from the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration's Reassessment and Uptake Working Group. Curr Oncol. 2021 Oct 16;28(5):4174-4183. doi: 10.3390/curroncol28050354. PMID: 34677272.

Erickson AW, Habbous S, Wright F, Lofters AK, Jerzak KJ, Das S. Assessing the Association of Targeted Therapy and Intracranial Metastatic Disease. JAMA Oncol. 2021 Aug 1;7(8):1220-1224. doi: 10.1001/jamaoncol.2021.1600. PMID: 34081080.

Evans JM, Gilbert JE, Bacola J, Hagens V, Simanovski V, Holm P, Harvey R, Blake PG, Matheson G. What do end-users want to know about managing the performance of healthcare delivery systems? Co-designing a context-specific and practice-relevant research agenda. Health Res Policy Syst. 2021 Oct 11;19(1):131. doi: 10.1186/s12961-021-00779-x. PMID: 34635106.

Evans JM, Wheeler SM, Sati S, Gradin S, MacKinnon M, Blake PG. Assessing the Delivery of Coordinated Care to Patients with Advanced Chronic Kidney Disease in Ontario, Canada: A Survey of Patients and Healthcare Professionals. Int J Integr Care. 2021 Jun 22;21(2):30. doi: 10.5334/ijic.5587. PMID: 34220394.

Gagliardi AR, Yip CYY, Irish J, Wright FC, Rubin B, Ross H, Green R, Abbey S, McAndrews MP, Stewart DE. The psychological burden of waiting for procedures and patient-centred strategies that could support the mental health of wait-listed patients and caregivers during the COVID-19 pandemic: A scoping review. Health Expect. 2021 Jun;24(3):978-990. doi: 10.1111/hex.13241. Epub 2021 Mar 26. PMID: 33769657.

Graili P, Ieraci L, Hosseinkhah N, Argent-Katwala M. Artificial intelligence in outcomes research: a systematic scoping review. Expert Rev Pharmacoecon Outcomes Res. 2021 Aug;21(4):601-623. doi: 10.1080/14737167.2021.1886083. Epub 2021 Feb 17. PMID: 33554681.

Grunau B, Asamoah-Boaheng M, Lavoie PM, Karim ME, Kirkham TL, Demers PA, Barakauskas V, Marquez AC, Jassem AN, O'Brien SF, Drews SJ, Haig S, Cheskes S, Goldfarb DM. A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval. Clin Infect Dis. 2021 Nov 30:ciab938. doi: 10.1093/cid/ciab938. Epub ahead of print. PMID: 34849655.

Habash M, Sheppard AJ, Steiner R. An evaluation of Indigenous Tobacco Program smoking prevention workshops with First Nations youth in Ontario, Canada. Can J Public Health. 2021 Aug;112(4):697-705. doi: 10.17269/s41997-021-00493-9. Epub 2021 Apr 8. PMID: 33830477.

Habbous S, Yermakhanova O, Forster K, Holloway CMB, Darling G. Variation in Diagnosis, Treatment, and Outcome of Esophageal Cancer in a Regionalized Care System in Ontario, Canada. JAMA Netw Open. 2021 Sep 1;4(9):e2126090. doi: 10.1001/jamanetworkopen.2021.26090. PMID: 34546371.

Haque MZ, Young SW, Wang Y, Harris S, Giesbrecht N, Chu M, Truscott R. Socio-demographic factors related to binge drinking in Ontario. Drug Alcohol Depend. 2021 Sep 1;226:108810. doi: 10.1016/j.drugalcdep.2021.108810. Epub 2021 Jun 18. PMID: 34218005.

Huber RM, Cavic M, Kerpel-Fronius A, Viola L, Field J, Jiang L, Kazerooni EA, Koegelenberg CF, Mohan A, Sales Dos Santos R, Ventura L, Wynes M, Yang D, Zulueta J, Lee CT, Tammemagi CM, Henschke CI, Lam S; Diagnostics Working Group; ED and Screening Committee. Lung Cancer Screening Considerations During Respiratory Infection Outbreaks, Epidemics or Pandemics: An IASLC Early Detection and Screening Committee Report. J Thorac Oncol. 2021 Dec 2:S1556-0864(21)03326-8. doi: 10.1016/j.jtho.2021.11.008. Epub ahead of print. PMID: 34864164.

Jamal S, Jones C, Walker J, Mazereeuw M, Sheppard AJ, Henry D, Marrett LD. Cancer in First Nations people in Ontario, Canada: Incidence and mortality, 1991 to 2010. Health Rep. 2021 Jun 16;32(6):14-28. doi: 10.25318/82-003-x202100600002-eng. PMID: 34142787.

Lofters AK, O'Brien MA, Sutradhar R, Pinto AD, Baxter NN, Donnelly P, Elliott R, Glazier RH, Huizinga J, Kyle R, Manca DM, Pietrusiak MA, Rabeneck L, Riordan B, Selby P, Sivayoganathan K, Snider C, Sopcak N, Thorpe K, Tinmouth J, Wall B, Zuo F, Grunfeld E, Paszat L. Building on existing tools to improve chronic disease prevention and screening in public health: a cluster randomized trial. BMC Public Health. 2021 Aug 3;21(1):1496. doi: 10.1186/s12889-021-11452-x. PMID: 34344340.

McLeod SL, Grewal K, Thompson C, Thabane L, Borgundvaag B, Ovens H, Scott S, Ahmed T, Mittmann N, Worster A, Agoritsas T, Guyatt G. Influence of electronic triage decision-support on hospital admission, left without being seen and time to physician initial assessment in the emergency department. CJEM. 2021 Mar;23(2):214-218. doi: 10.1007/s43678-020-00043-1. Epub 2021 Jan 8. PMID: 33709360.

McMorris CA, Lake J, Dobranowski K, McGarry C, Lin E, Wilton D, Lunsky Y, Balogh R. Psychiatric disorders in adults with cerebral palsy. Res Dev Disabil. 2021 Apr;111:103859. doi: 10.1016/j.ridd.2021.103859. Epub 2021 Jan 29. PMID: 33524738.

Meggetto O, Jembere N, Gao J, Walker MJ, Rey M, Rabeneck L, Murphy KJ, Kupets R; Ontario Cervical Screening Program / Colposcopy COVID-19 Working Group [members: Coulson M, McCurdy BR, Stogios C, Wallace J, Wang L]. The impact of the COVID-19 pandemic on the Ontario Cervical Screening Program, colposcopy and treatment services in Ontario, Canada: a population-based study. BJOG. 2021 Aug;128(9):1503-1510. doi: 10.1111/1471-0528.16741. Epub 2021 May 31. PMID: 33982870.

Milkovich J, Hanna T, Nessim C, Petrella TM, Weatherhead L, Chan AW, Irish JC, Murray C, Bannerman G, Holloway C, Forster K, Pazzano L, Wright FC, The Ontario Skin Cancer Advisory Committee. Restructuring Skin Cancer Care in Ontario: A Provincial Plan. Curr Oncol. 2021 Mar 12;28(2):1183-1196. doi: 10.3390/curroncol28020114. PMID: 33809399.

Mofidi A, Tompa E, Song C, Tenkate T, Arrandale V, J Jardine K, Davies H, Demers PA. Economic evaluation of interventions to reduce solar ultraviolet radiation (UVR) exposure among construction workers. J Occup Environ Hyg. 2021 Jun;18(6):250-264. doi: 10.1080/15459624.2021.1910278. Epub 2021 May 14. PMID: 33989124.

Morgan E, Arnold M, Rutherford M, Bardot A, Ferlay J, De P, Engholm G, Jackson C, Little A, Saint-Jacques N, Walsh P, Woods RR, O'Connell DL, Bray F, Parkin DM, Soerjomataram I. The impact of reclassifying cancers of unspecified histology on international differences in survival for small cell and non-small cell lung cancer (ICBP SurvMark-2 project). Int J Cancer. 2021 Sep 1;149(5):1013-1020. doi: 10.1002/ijc.33620. Epub 2021 May 20. PMID: 33932300.

Naipaul RD, Mercer RE, Chan KKW, Yeung L, Forbes L, Gavura S. Clinician Perspectives of COVID-19-Related Cancer Drug Funding Measures in Ontario. Curr Oncol. 2021 Feb 26;28(2):1056-1066. doi: 10.3390/curroncol28020103. PMID: 33652898.

Nnorom O, Sappong-Kumankumah A, Olaiya OR, Burnett M, Akor N, Shi N, Wright P, Gebreyesus A, Gebremikael L, Lofters A. Afrocentric screening program for breast, colorectal, and cervical cancer among immigrant patients in Ontario. Can Fam Physician. 2021 Nov;67(11):843-849. doi: 10.46747/cfp.6711843. PMID: 34772714.

Papadakos J, Barnsley J, Berta W, Rowlands G, Samoil D, Howell D. The association of self-efficacy and health literacy to chemotherapy self-management behaviors and health service utilization. Support Care Cancer. 2022 Jan;30(1):603-613. doi: 10.1007/s00520-021-06466-5. Epub 2021 Aug 4. PMID: 34347182.

Perl J, Thomas D, Tang Y, Yeung A, Ip J, Oliver M, Blake P. COVID-19 Among Adults Receiving Home Versus In-Center Dialysis. Clin J Am Soc Nephrol. 2021 Sep;16(9):1410-1412. doi: 10.2215/CJN.04170321. Epub 2021 Jun 4. PMID: 34088719.

Quartey NK, Papadakos J, Umakanthan B, Giuliani ME. Pivoting the Provision of Smoking Cessation Education in a Virtual Clinical World: The Princess Margaret Cancer Centre Experience. Curr Oncol. 2021 Dec 15;28(6):5395-5400. doi: 10.3390/curroncol28060449. PMID: 34940088.

Rutherford MJ, Arnold M, Bardot A, Ferlay J, De P, Tervonen H, Little A, Bucher O, St Jacques N, Gavin A, Engholm G, Møller B, O'Connell DL, Merrett N, Parkin DM, Bray F, Soerjomataram I. Comparison of liver cancer incidence and survival by subtypes across seven high-income countries. Int J Cancer. 2021 Dec 15;149(12):2020-2031. doi: 10.1002/ijc.33767. Epub 2021 Sep 14. PMID: 34460109.

Singh S, Fletcher GG, Yao X, Sussman J. Virtual Care in Patients with Cancer: A Systematic Review. Curr Oncol. 2021 Sep 8;28(5):3488-3506. doi: 10.3390/curroncol28050301. PMID: 34590602.

Shapiro GD, Sheppard AJ, Mashford-Pringle A, Bushnik T, Kramer MS, Kaufman JS, Yang S. Housing conditions and adverse birth outcomes among Indigenous people in Canada. Can J Public Health. 2021 Oct;112(5):903-911. doi: 10.17269/s41997-021-00527-2. Epub 2021 May 26. PMID: 34037966.

Singh S, Farrelly A, Chan C, Nicholls B, Nazeri-Rad N, Bellicoso D, Eisen A, Falkson CB, Fox C, Holloway C, Kennedy E, McLeod R, Rothenberger D, Trudeau M, Shanafelt T, Bauman G. Prevalence and Workplace Drivers of Burnout in Cancer Care Physicians in Ontario, Canada. JCO Oncol Pract. 2022 Jan;18(1):e60-e71. doi: 10.1200/OP.21.00170. Epub 2021 Sep 10. PMID: 34506217.

Sniekers DC, Jung JKH, Blake PG, Cooper R, Leis JA, Muller MP, Padure V, Holm P, Yeung A, Taji L, McFarlane P, Oliver MJ. Province-Wide Prevalence Testing for SARS-CoV-2 of In-Center Hemodialysis Patients and Staff in Ontario, Canada: A Cross-Sectional Study. Can J Kidney Health Dis. 2021 Aug 5;8:20543581211036213. doi: 10.1177/20543581211036213. PMID: 34394945.

Taji L, Thomas D, Oliver MJ, Ip J, Tang Y, Yeung A, Cooper R, House AA, McFarlane P, Blake PG. COVID-19 in patients undergoing long-term dialysis in Ontario. CMAJ. 2021 Feb 22;193(8):E278-E284. doi: 10.1503/cmaj.202601. Epub 2021 Feb 4. PMID: 33542093.

Tammemägi MC, Darling GE, Schmidt H, Llovet D, Buchanan DN, Leung Y, Miller B, Rabeneck L. Selection of individuals for lung cancer screening based on risk prediction model performance and economic factors - The Ontario experience. Lung Cancer. 2021 Jun;156:31-40. doi: 10.1016/j.lungcan.2021.04.005. Epub 2021 Apr 20. PMID: 33887677.

Ugas MA, Samoil D, Avery L, Berlin A, Giuliani ME, Papadakos TJ, Quartey NKL, Papadakos JK. COVID-19 and patients with cancer: Investigating treatment impact, information sources, and COVID-19-related knowledge, attitudes, and practices. Cancer. 2021 Oct 27. doi: 10.1002/cncr.33976. Epub ahead of print. PMID: 34705287.

Walker MJ, Meggetto O, Gao J, Espino-Hernández G, Jembere N, Bravo CA, Rey M, Aslam U, Sheppard AJ, Lofters AK, Tammemägi MC, Tinmouth J, Kupets R, Chiarelli AM, Rabeneck L. Measuring the impact of the COVID-19 pandemic on organized cancer screening and diagnostic follow-up care in Ontario, Canada: A provincial, population-based study. Prev Med. 2021 Oct;151:106586. doi: 10.1016/j.ypmed.2021.106586. PMID: 34217413.

Yardman-Frank JM, Glassheim E, Kricker A, Armstrong BK, Marrett LD, Luo L, Cust AE, Busam KJ, Orlow I, Gallagher RP, Gruber SB, Anton-Culver H, Rosso S, Zanetti R, Sacchetto L, Kanetsky PA, Dwyer T, Venn A, Lee-Taylor J, Begg CB, Thomas NE, Berwick M. Differences in Melanoma Between Canada and New South Wales, Australia: A Population-Based Genes, Environment, and Melanoma (GEM) Study. JID Innov. 2021 Mar;1(1):100002. doi: 10.1016/j.xjidi.2021.100002. Epub 2021 Jan 25. PMID: 33768212.

Yohanna S, Naylor KL, Mucsi I, McKenzie S, Belenko D, Blake PG, Coghlan C, Dixon SN, Elliott L, Getchell L, Ki V, Nesrallah G, Patzer RE, Presseau J, Reich M, Sontrop JM, Treleaven D, Waterman AD, Zaltzman J, Garg AX. A Quality Improvement Intervention to Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) in Patients With Chronic Kidney Disease: Clinical Research Protocol of a Cluster-Randomized Clinical Trial. Can J Kidney Health Dis. 2021 Apr 15;8:2054358121997266. doi: 10.1177/2054358121997266. PMID: 33948191.

Articles by external researchers utilizing CCO data

Bhatia D, Sutradhar R, Austin PC, Giannakeas V, Jaakkimainen L, Paszat LF, Lipscombe LL. Periodic screening for breast and cervical cancer in women with diabetes: a population-based cohort study. Cancer Causes Control. 2021 Nov 20. doi: 10.1007/s10552-021-01517-y. Epub ahead of print. PMID: 34800194.

Gupta S, Sutradhar R, Li Q, Coburn N. The effectiveness of a provincial symptom assessment program in reaching adolescents and young adults with cancer: A population-based cohort study. Cancer Med. 2021 Dec;10(24):9030-9039. doi: 10.1002/cam4.4401. Epub 2021 Nov 5. PMID: 34738747.

Lofters AK, Gatov E, Lu H, Baxter NN, Corrado AM, Guilcher SJT, Kopp A, Vahabi M, Datta GD. Stage of colorectal cancer diagnosis for immigrants: a population-based retrospective cohort study in Ontario, Canada. Cancer Causes Control. 2021 Dec;32(12):1433-1446. doi: 10.1007/s10552-021-01491-5. Epub 2021 Aug 31. PMID: 34463874.

Malagón T, Yong JHE, Tope P, Miller WH Jr, Franco EL; McGill Task Force on the Impact of COVID-19 on Cancer Control and Care. Predicted long-term impact of COVID-19 pandemic-related care delays on cancer mortality in Canada. Int J Cancer. 2021 Nov 29. doi: 10.1002/ijc.33884. Epub ahead of print. PMID: 34843106.

Metcalfe A, Cairncross ZF, Friedenreich CM, Ray JG, Nelson G, Fell DB, Lisonkova S, Bhatti P, McMorris C, Sikdar KC, Shack L. Incidence of Pregnancy-Associated Cancer in Two Canadian Provinces: A Population-Based Study. Int J Environ Res Public Health. 2021 Mar 17;18(6):3100. doi: 10.3390/ijerph18063100. PMID: 33802896.

Nadler MB, Ivers N, Marchand-Austin A, Lofters A, Austin PC, Wilson BE, Desnoyers A, Amir E. Patient and provider determinants of breast cancer screening among Ontario women aged 40-49: a population-based retrospective cohort study. Breast Cancer Res Treat. 2021 Oct;189(3):631-640. doi: 10.1007/s10549-021-06344-y. Epub 2021 Aug 19. PMID: 34414531.

Raphael MJ, Gupta S, Wei X, Peng Y, Soares CN, Bedard PL, Siemens DR, Robinson AG, Booth CM. Long-Term Mental Health Service Utilization Among Survivors of Testicular Cancer: A Population-Based Cohort Study. J Clin Oncol. 2021 Mar 1;39(7):779-786. doi: 10.1200/JCO.20.02298. Epub 2021 Jan 28. PMID: 33507821.

Seung SJ, Hurry M, Hassan S, Elnoursi A, Scheider KAB, Wagner D, Edwin JJ, Aw ATW. Examining Treatment Patterns and Real-World Outcomes in Chronic Lymphocytic Leukemia Using Administrative Data in Ontario. Curr Oncol. 2021 Nov 19;28(6):4832-4844. doi: 10.3390/curroncol28060408. PMID: 34898565.

Vahabi M, Lofters AK, Kopp A, Glazier RH. Correlates of non-adherence to breast, cervical, and colorectal cancer screening among screen-eligible women: a population-based cohort study in Ontario, Canada. Cancer Causes Control. 2021 Feb;32(2):147-155. doi: 10.1007/s10552-020-01369-y. Epub 2021 Jan 4. PMID: 33392906.

Velez MP, Richardson H, Baxter NN, McClintock C, Greenblatt E, Barr R, Green M. Risk of infertility in female adolescents and young adults with cancer: a population-based cohort study. Hum Reprod. 2021 Jun 18;36(7):1981-1988. doi: 10.1093/humrep/deab036. PMID: 33611573.